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pentobarbital will lower the extent or impact of quetiapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.Monitor Carefully (1)pentobarbital will minimize the extent or outcome of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lack of, or lessened response to tofaciti